As an example of how AlphaFold models and 3Dmapper can be useful, we studied mutations in the DNA repair protein XRCC2, which interacts with RAD51D to repair DNA double-strand breaks (Baldock et al. 2019) and is associated with cancer-related mutations (https://www.mycancergenome.org/content/gene/xrcc2/). The gene discussed is RAD51D; the disease is cancer.