A recent publication reported the loss of specific immunological protection in the affected twin in a genome study of discordant twins.30The immunological theory would explain cell loss in the lateral hypothalamus in patients with narcolepsy due to self-harm due to an imbalance in the immune complex formed by TCR, HLA, and CD40L.17, 21, 29Furthermore, patients with narcolepsy with cataplexy have more specific tribbles homolog two antibodies, which, although present in all patients with narcolepsy, would be more prevalent in the initial phase of the disease.31 Here, CD40LG is linked to Cataplexy.