Due to this discrepancy, the HLA-DQB1*0602 allele is no longer used in clinical practice.22Nevertheless, the HLA-DQB1*0602 allele holds predictive value for individual variations in average sleep conditions, especially in sleep deprivation situations.17Fernandes et al.17demonstrated that the association between the HLA-DQB1*0602 allele and cataplexy could predict hypocretin-1 deficiency, offering potential utility in diagnosing diagnosis and treatment of narcolepsy. This evidence concerns the gene HCRT and Cataplexy.