NFE2L2 and Creutzfeldt Jacob disease: In scrapie-infected murine neuroblastoma N2a (ScN2a) cells, we addressed the effect of ACNs for the reduction of ROS levels through the activation of the Keap1-Nrf2 pathway, and the reduction of PrPSc aggregates in ScN2a22L cells, and also the inhibition of the formation of PrPSc fibrils in the Cerebrospinal fluid (CSF) of CJD patients.