SERPINE1 and disease of the tendon: Upon loadingthe developed LPNs nanoplatform with the relevantpayloads, the synergistic anti-inflammatory and antifibrotic effectsof budesonide and serpine1 siRNA dual-loaded LPNs were tested in murineand human macrophage cell lines and in human primary macrophages.The modulation of the expression of genes and proteins related toinflammation and the TGF-β1/PAI-1 signaling pathway associatedwith fibrosis in tendon disease was assessed through different molecularbiology techniques.