Similarly, we have previously shown (using the same patient cohort) that concomitant Ss infection exhibited diminished systemic levels of cytokine, chemokine, adipokine, and hormonal responses that favour protection from insulin resistance, pancreatic beta cell exhaustion, and angiogenic factors and soluble receptor for advanced glycation end product (RAGE) ligands and these levels were significantly reversed following anthelmintic treatment. Here, AGER is linked to Insulin resistance.