C4A and diabetes mellitus: To determine the effect of anthelmintic treatment in Ss+ DM+ individuals on the systemic levels of C1q, C2, C3, C4, C4b, C5, C5a, MBL (Lectin) complement proteins and complement regulatory proteins like Factor B, Factor D, Factor H, and Factor I. At 6 months following anthelmintic treatment, as shown in Fig 3, the levels of C1q (percentage increase of 15%; p = 0.0012), C4b (percentage increase of 11%; p<0.0001), and MBL (Lectin) (percentage increase of 11%; p = 0.0201) increased following treatment.