To examine the impact of Ss infection on complement proteins and complement regulatory proteins in DM, we quantified the systemic levels of C1q, C2, C3, C4, C4b, C5, C5a, MBL (Lectin) complement proteins and complement regulatory proteins, Factor B, Factor D, Factor H and factor I in Ss+DM+ and Ss-DM+ individuals. This evidence concerns the gene C3 and diabetes mellitus.