Two key unanswered questions were of particular interest: (1) is it hepatocyte-specific MCT1 depletion that protects mice with MCT1 haploinsufficiency from liver lactate overload and NAFLD and (2) does liver stellate cell MCT1 promote hepatic fibrogenesis that occurs in NASH? The gene discussed is SLC16A1; the disease is metabolic dysfunction-associated steatohepatitis.