Among the 163 upregulated genes, we did not observe a clear enrichment of Gene Ontology processes but did obtain significant enrichment of genes associated with hearing loss, including the upregulation of Otof, Tectb, Cldn11, Sall1, Cldn14, Chrna10, Esprn, and Fgfr3 (Table S1). The gene discussed is CLDN11; the disease is hearing loss disorder.