Nadir CD4+ less than 200, CD8+ T cells, and history of IRIS were also linked to CH with an OR of 3.18 (95% CI 1.22–9.29), OR of 1.06 (95% CI 1.02–1.11), and OR of 2.34 (95% CI 1.06–5.29), respectively. The gene discussed is CD4; the disease is cyclic hematopoiesis.