DNMT3A and cyclic hematopoiesis: Logistic regression analysis for associations of DNMT3A-CH (controlling for the same 5 cofactors as for CH risk overall) identified prior IRIS and CD8+ T cells as the only significant association (OR 2.53 [95% CI 1.03–6.33] and OR 1.07 per increase of 50 cells/μL [95% CI 1.02–1.12], respectively) (Supplemental Figure 2).