We next explored HIV-associated variables that could impact the risk of CH development and expansion, including current CD4+ and CD8+ T cell counts, CD4+/CD8+ ratio, nadir CD4+ count, prior mycobacterial infection or other chronic OIs (KSHV, histoplasmosis, cryptococcosis, toxoplasmosis), history of inflammatory complications including IRIS with or without HLH, and LTNP/EC status (Supplemental Table 1). The gene discussed is CD8A; the disease is cyclic hematopoiesis.