For every increase in CD8+ T cells of 50 cells/μL there was an increased risk of CH by an OR of 1.08 (95% CI 1.04–1.13), and for each increase in nadir CD4+ count of 50 cells/μL, there was a decrease in the OR for CH of 0.91 (95% CI 0.83–0.98). This evidence concerns the gene CD8A and cyclic hematopoiesis.