Using a forward selection multivariate logistic regression model selecting significant variables from the prior models while also including the original baseline cofactors, only increasing age (OR 1.07, 95% CI 1.03–1.11), CD8+ T cells (OR 1.08, 95% CI 1.03–1.13), and nadir CD4+ less than 200 (OR 3.03, 95% CI 1.19–8.46) remained statistically associated with a greater risk of CH. The gene discussed is CD4; the disease is cyclic hematopoiesis.