(F) Primary samples from acute myeloid leukemia (AML) patients with the FLT3ITD-TKD mutation (n=2, yellow bars) or the FLT3ITD-JMD/TKD mutation (n=3, blue bars) were exposed to Midostaurin (100 nM, PKC412), and JNK inhibitor (10 μM, SP600125) for 48 hr, or combinations thereof. This evidence concerns the gene MAPK8 and acute myeloid leukemia.