TRPA1 and Parkinson disease: However, to date, the TRPA1 channel has not been linked with NCS-1, although some of the most essential functions of TRPA1 appear to require a close relationship with this Ca2+ sensor, such as memory [51], neuronal survival [30, 31, 58, 59], cell death [15, 70], Parkinson’s disease [17, 43], CIPN [2, 44], and cancer [18, 55, 63].