There for, our research focuses on exploring the impact of modulating autophagy on the release of β-amyloid and tau proteins through exosomes in animal models of Alzheimer’s disease (AD), We will examine the role of autophagy in regulating the quantity and composition of exosomes carrying these disease-associated proteins, to provide a new promising therapeutic strategy for the prevention and treatment of AD. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.