[225Ac]Ac-macropa conjugated compounds with one or two albumin- and PSMA-targeting moieties (mcp-M-alb-PSMA and mcp-d-alb-PSMA, Fig. 17b, c) prolonged the blood circulation time, specifically and highly accumulated in the tumor, and inhibited tumor growth with DNA double-strand break formation [160]. The gene discussed is ALB; the disease is neoplasm.