Another mouse model induced by PTEN deletion shows progression of epidermal hyperplasia, hypergranulosis, hyperkeratosis, mammary adenosquamous carcinoma, adenomyoepithelioma [19, 20], and cutaneous SCC, accompanied by hyperactivation of mTOR and production of fibroblast growth factor (FGF) [20]. Here, MTOR is linked to Hyperkeratosis.