We observed the level of the apoptotic cell marker caspase-3 and STING/TBK1/IRF3 activation was increased with dose-dependent manner in both MSS-CRC cell lines (HT29, CoLo320DM, and CT26) and MSI-CRC cell line (HCT116, Fig. 2A). This evidence concerns the gene IRF3 and colorectal carcinoma.