SVYRYYGL(SVY) peptides placed on mouse MHC (Major Histocompatibility Complex) bound to a model TCR (T-cell receptor) specific for the KbSIY complex, but in a different conformation, according to investigations using molecular dynamics simulations by Catherine A. Bessell et al. With a preference for either SIY or SVY, heterozygous CD8+ T cell populations grown from wild-type C57BL/6 mice reacted cross-reactively with bacterial and tumor antigens. This evidence concerns the gene CD8A and neoplasm.