In addition, although myeloid population frequencies were not substantially altered at this time point, a strong induction of the IFNγ response signature could be detected across all myeloid clusters (Supplementary Fig. S9F–S9J), which may be consistent with augmented IFNγ production by tumor antigen–reactive CD8+ TILs following CD8-mIL2 therapy. This evidence concerns the gene IFNG and neoplasm.