Analysis of TILs from MC38 tumors with MHC tetramers loaded with the H-2Kb-restricted neoantigen Rpl18 (40) likewise showed increased numbers of tumor antigen–reactive CD8+ T cells and decreased expression of PD-1 following therapy with CD8-mIL2 (Supplementary Fig. S6A–S6E). The gene discussed is HLA-C; the disease is neoplasm.