STAT3 and cancer: Additionally, it has the ability to efficiently suppress the growth of breast tumors through various mechanisms, such as reducing the activity of cancer stem-like cells (CSCs) and myeloid-derived suppressor cells (MDSCs) that promote cancer stemness, inhibiting epithelial-mesenchymal transition (EMT), blocking the STAT3-dependent pathway, suppressing tumor-derived cytokines, and interfering with the NOTCH signaling pathway (Song et al. 2020).