MAPT and early-onset autosomal dominant Alzheimer disease: Tau pathology plays a crucial role in neurodegeneration diseases with tauopathy including Alzheimer’s disease (AD), the most common type of dementia (Gale et al. 2018; Hachinski 2019), and non-AD disease, such as progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) (Sengupta and Kayed 2022; Vasilevskaya et al. 2020).