SON and viral infectious disease: SON is involved in the regulating several type I IFN-inducible proteins and is associated with the inhibition of viral infection.73,74PRPF19, ABCF2 and EFTUD2 also correlate with the genesis of some immune cells and production of cytokines ,75 , .76,77 Notably, genes associated with interleukins, addressin, and antivirus immunity are mainly correlated with GI immune tissues (Peyer’s patch, MLN) and spleen (Fig. S10A, B).