IL-1 has repeatedly been shown to affect myelopoiesis.21 Blockade of IL-1β or NLRP3 inflammasome limits myelopoiesis in atherosclerotic mice,22 and IL-1β blockade limits myelopoiesis after myocardial infarction.54 In line with these previous reports, we observed reduced numbers of HSCs and multipotent progenitors in the bone marrow of mice treated with anti-IL1RAP. The gene discussed is NLRP3; the disease is myocardial infarction.