Cytokines play a central role in development of atherosclerosis.1,2 Our study demonstrates that blockade of IL1RAP, a signalling co-receptor of IL-1, IL-33, and IL-36 signalling, limits plaque burden as well as chemokine expression and myeloid cell accumulation in atherosclerotic Apoe−/− mice. Here, APOE is linked to atherosclerosis.