IL1RAP and acute myocardial infarction: Previous reports have shown that IL1RAP-related cytokines also target fibroblasts,18,26,27 and fibroblasts contribute to the inflammatory response as well as to infarct size and cardiac remodelling post-acute myocardial infarction.28,29 IL1RAP expression on NIH3T3 fibroblasts and BMDM before stimulation was detected by flow cytometry (Figure 6F and G).