Thus, STING pathway inhibitorscould have therapeutic application in many of these inflammatory conditions.The cGAS inhibitor RU.521 and the STING inhibitor H-151 have shownpromise as therapeutics in mouse models of colitis, ALS, and more.However, these agents require frequent high-dose intraperitoneal injections,which may limit translatability. The gene discussed is CGAS; the disease is colitis.