Aberrant activation of the cyclic GMP-AMP synthase (cGAS)/Stimulatorof Interferon Genes (STING) pathway has been implicated in the developmentand progression of a myriad of inflammatory diseases including colitis,nonalcoholic steatohepatitis, amyotrophic lateral sclerosis (ALS),and age-related macular degeneration. The gene discussed is CGAS; the disease is age-related macular degeneration.