AKT1 and colorectal carcinoma: By regulating gene expression and modification, lncRNAs are involved in various signaling pathways, such as Wnt/β-catenin, PI3K/Akt, and EMT, which affect the proliferation, metastasis, and prognosis of CRC (Duan et al., 2020; Zhang et al., 2021; Zhang et al., 2018).