Consistent with the above findings, GPX4 inactivation using ferroptosis inhibitors such as ferrostatin-1 and liproxstatin-1 was lethal in xenograft models in many human diseases including acute renal failure, ischemia/reperfusion injury, neurodegenerative diseases, and cancers (Shi et al., 2021). The gene discussed is GPX4; the disease is neurodegenerative disease.