In fact, a previous Spearman correlation analysis revealed that the Eubacterium_fissicatena_group was positively associated with proinflammatory markers such as TNF-α, IL-6, and IL-8, negatively associated with anti-inflammatory markers such as IL-10, and associated with colonic inflammation in inflammatory bowel disease (IBD) (Liu et al., 2022). The gene discussed is TNF; the disease is colitis.