We also recapitulate the current understanding of the HCN channels in the nervous system (Biel et al., 2009; Wahl-Schott and Biel, 2009; Benarroch, 2013) and pathologies related to their malfunction including epilepsy, neuropathic pain, and Parkinson’s disease, thereby opening the ways for therapeutic approaches targeting these channels. This evidence concerns the gene MALAT1 and Parkinson disease.