To further determine the clinical significance of CDKL3 in ESCA patients, our study of clinical data from the TCGA-ESCA dataset revealed a significant association between high CDKL3 expression and pathology (squamous cell carcinoma vs. adenocarcinoma), race (Asian vs. White), T (T3 vs. T1) and tumor stage (stage II&III vs. stage I) (Figure 2A). This evidence concerns the gene CDKL3 and adenocarcinoma.