In EVs derived from melanoma, specific miRNAs, including miR-3187-3p, miR-498, miR-122, miR-149, and miR-181a/b, were found to downregulate T cell receptor (TCR) signaling and the secretion of tumor necrosis factor-α (TNF-α) in CD8+ T cells (50). The gene discussed is CD8A; the disease is melanoma.