Also, a gene expression signature obtained from tumor biopsies containing the gene (ITGAE) encoding for CD103 among other TIL-related genes (CD8A, CD8B, ITGAE [CD103], PDCD1 [PD-1], CCL5, CXCL13, and IL2) was associated with better outcomes to anti-PD1 therapy (44). This evidence concerns the gene ITGAE and neoplasm.