showed by implanting E-cadherin overexpressing B16F10 melanoma cells in wild-type, RAG−/−, and CD103−/− mice that E-cadherin expression, which initially led to reduced outgrowth in wild-type mice compared with CDH1 knockout B16F10s, requires functional CD103+ TRM cells for successful tumor eradication (39). This evidence concerns the gene ITGAE and melanoma.