ITGA5 and ovarian cancer: Furthermore, lycopene also downregulated the mRNA expression of integrin β1 (ITGB1), integrin α5 (ITGA5), focal adhesion kinase (FAK), integrin-linked kinase (ILK), matrix metalloproteinase 9 (MMP9) and the expression of epithelial to mesenchymal transition (EMT) inhibits the activity of mitogen-activated protein kinase (MAPK) and reduced the mRNA expression level of the ovarian cancer biomarker CA125, thereby inhibited the proliferation of primary ovarian cancer cells and metastatic cells in mice (76).