NOS2 and arthritic joint disease: Lycopene could activate the Nrf2/HO-1 signaling pathway, thereby inhibited the activation of theNF-κBandSTAT3pathways caused by interleukin-1β (IL-1β), limited tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) gene transcription, and then reduced TNF-α, IL-6 and prostaglandin content, and slow down arthritis in mice (98).