Utilizing digital spatial profiling, we analyzed the transcriptomes of 11 regions of interest (ROIs) within CD20+ infiltrates in a lymph node sample from a case of non-GC DLBCL, as classified by the Hans algorithm44, exhibiting MYC and BCL2 double-expression (Figure 6J; Supplementary Table 8). This evidence concerns the gene MYC and diffuse large B-cell lymphoma.