Indeed, the DZ is an MHC-I/-II-low environment; moreover, aggressive B-cell lymphomas with DZ-like transcriptional imprints display reduced MHC-I/-II gene expression and include MYC/BCL2 DH high-grade B-cell lymphomas displaying frequent mutations in MHC genes42. This evidence concerns the gene HLA-C and B-cell non-Hodgkin lymphoma.