A significant negative correlation with T cell signatures was identified for 107 DZ signature genes in at least three different DLBCL datasets (Figure 6C–D; Supplementary Figure 6A-B; Supplementary Table 6), indicating that a DZ spatial signature enriched in ATR-dependent DNA damage response and cell cycle checkpoints programs was negatively associated with T-cell content in DLBCL (Figure 6E; Supplementary Table 6). The gene discussed is ATR; the disease is diffuse large B-cell lymphoma.