On this same ground, overexpression of the nuclear pore component XPO1 has been suggested to compensate in aggressive B-cell lymphomas for MYC-induced replication stress through the induction of key replication checkpoints listed among our DZ spatial signature hallmarks such as RAD51, WEE1, and BRCA162. The gene discussed is MYC; the disease is B-cell non-Hodgkin lymphoma.