While we did not find significant association between the STAG3 variant and female infertility in the UK Biobank (P>0.05), we observed increased risk of idiopathic infertility in women carrying a novel testosterone-lowering variant in GPC2 (chr7:100171569:G:A, F-EXCL OR=2.63 (1.40–4.92), P=1.25E-03) (Figure 6B). The gene discussed is GPC2; the disease is female infertility.