We analysed the 450k UK Biobank exome sequencing dataset to characterise the association between rare coding variation (MAF<1%) and binary traits with >100 cases (F-ALL (3,746 cases, 260,413 controls), F-EXCL (3,012 cases, 261,147 controls), and M-ALL (650 cases, 222,393 controls)), and quantitative traits with >10,000 participants (FSH-F (N=20,800), LH-F (N=16,391), oestradiol-F (N=54,609), and testosterone (Nfemale=197,038, Nmale=197,340) (Figure 1)). This evidence concerns the gene PLOD1 and acute lymphoblastic leukemia.