We found 39 novel variants for testosterone in men, including those near SPOCK1 (rs1073917: β (SE)=−0.0160 (0.0029), P=4.69E-08), which is a target for the androgen receptor63, NR4A3 (rs10988865: β=−0.0161 (0.0029), P=4.33E-08), which coordinates the cellular response to corticotropin-hormone and thyrotropin-hormone releasing stimuli64,65 and regulates adipogenesis66, and obesity-associated genes ANKS1B (rs144998814: β=0.133 (0.0162), P=2.34E-16) and ANO10 (rs6809522: β=0.016 (0.0029), P=3.00E-08)67 (Supp. The gene discussed is ANO10; the disease is obesity due to melanocortin 4 receptor deficiency.