CALCA and pancreas disorder: To determine whether this was correlated with a difference in pancreatic disease burden, we evaluated the pancreata of a separate cohort of mice and found that compared to pancreata of KC Pikfyve+/+ littermates, pancreata of KC Pikfyvef/+ and KC Pikfyvef/f mice weighed less and were closer in weight to pancreata of wild-type mice at 27 weeks of age (Fig. 1J, Extended Data Fig. 1F).