In intervertebral disc degeneration (IDD), AD-MSCs-derived exosomal miR-155-5p showed to inhibit pyroptosis and promoted autophagy and ECM synthesis in nucleus pulposus cells, in-vitro, through targeting TGF beta receptor 2 (TGFβR2). This evidence concerns the gene TGFBR2 and intervertebral disk degenerative disorder.