SQSTM1 and diabetes mellitus: In patients with diabetes, YTHDC1 downregulation induces decreased SQSTM1 expression through accelerated SQSTM1 nuclear mRNA decay, leading to disturbed autophagic flux and keratinocyte migration, thus delaying wound healing (Figure 3) (Moscat and Diaz-Meco, 2009; Katsuragi et al., 2015).