In patients with these variants, platelet disorders might be overlooked because of (1) bleeding is more frequently associated with variants in the motor domain than variants in the neck and the tail and (2) a tendency toward bleeding (e.g., easy bruising, epistaxis and gum bleeding) can manifest differently even between a parent and a child harboring the same variant of MYH9 (Saposnik et al., 2014). Here, MYH9 is linked to blood platelet disease.