In humans, variants of two genes encoding class-II conventional myosins, MYH9 and MYH14, and four genes encoding class-IIIA, -VI, -VIIA and -XVA unconventional myosins, MYO3A, MYO6, MYO7A and MYO15A, are presently associated with autosomal dominant or recessive nonsyndromic sensorineural hearing loss (Table 1). This evidence concerns the gene MYH14 and autosomal dominant nonsyndromic hearing loss.