In humans, variants of two genes encoding class-II conventional myosins, MYH9 and MYH14, and four genes encoding class-IIIA, -VI, -VIIA and -XVA unconventional myosins, MYO3A, MYO6, MYO7A and MYO15A, are presently associated with autosomal dominant or recessive nonsyndromic sensorineural hearing loss (Table 1). The gene discussed is MYO6; the disease is autosomal dominant nonsyndromic hearing loss.