Previous RNA-seq studies of Bph15 introgression lines and recipient lines before and after BPH infestation have identified key defense mechanisms associated with phytohormone signaling, mitogen-activated protein kinase (MAPK) cascades, receptor kinases, protein post-translational modifications, TFs, Ca2+ signaling, and pathogenesis-related proteins (Lv et al., 2014). The gene discussed is WNK2; the disease is benign prostatic hyperplasia.