LOX and oral cavity squamous cell carcinoma: Although the association of LOX with collagen fibers and its downstream effect are somewhat vague in gastric CAFs, recent evidence claimed that small extracellular vesicles secreted by oral squamous cell carcinoma (OSCC) CAFs, which contain active LOX, interact with fibronectin and periostin to bind to collagen fibers through integrin 2αβ1 (Liu et al., 2023).