The most upregulated genes AABR07046778.1, Ngfr, Nudt10, LOC100360647, AC136661.1, Fau, Sdc1, LOC100360491,LOC100910678, and Snrpg. The glutamate excitotoxicity associated with mitochondrial dysfunction can cause tinnitus [33]. This evidence concerns the gene SDC1 and Tinnitus.