The most downregulated genes in the tinnitus (when compared to the non-tinnitus group) were LOC103690064, AABR07048397.1, Trpv1, AABR07061378.1, Ncaph, Spata20, Rps19, Enpp3, Grtp1, and Glra1. This evidence concerns the gene ENPP3 and Tinnitus.