For instance, Nifurtimox (Rolon et al., 2022; Xin et al., 2022; Eslin et al., 2023), utilized in the treatment of Chagas disease and recurrent neuroblastoma, and Venetoclax (Li et al., 2024a), a Bcl-2 inhibitor used for managing chronic lymphocytic leukemia, both feature nitro structures. Here, BCL2 is linked to neuroblastoma.