ACE and hypertensive disorder: Similar results demonstrated that resveratrol administration can protect male offspring from hypertension accompanied by a significant downregulation of angiotensinogen, renin, prorenin receptor, angiotensin-converting enzyme (ACE), angiotensin II type 1 receptor (AT1R), but increased ACE2, angiotensin II type 2 receptor (AT2R) and angiotensin (1–7) receptor MAS (Hsu et al., 2021).