Endothelial inflammation plays a pivotal role in the progression of atherosclerosis and CVD (Haybar et al., 2019) leading to the production of proinflammatory mediators such as interleukin (IL)-8, chemokines, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), P-selectin, E-selectin, vascular adhesion molecule-1 (VCAM-1), and other inflammatory factors that attract monocyte and neutrophils which penetrate the arterial wall initiating the inflammatory process of atherogenesis (Chistiakov et al., 2018). Here, CCL2 is linked to atherosclerosis.