Resveratrol supplementation effectively reduced TMA production, and consequently, derived metabolite (TMAO), and regulated bile acid metabolism in both C57BL6J and ApoE −/− mice (Chen et al., 2016) as well as reduced atherosclerotic lesion size, alleviated hyperlipidemia, ameliorated hepatic lipid accumulation, and promoted lipid metabolism in ApoE −/− mice (Cheng et al., 2023). The gene discussed is APOE; the disease is hyperlipidemia.