Another study investigated the relationship between single-nucleotide polymorphisms of the apolipoprotein E gene, rs725960, rs440446, rs769449, rs429358, rs7412, rs1065853, and rs439401, and essential hypertension (EH) in the Guizhou population and found that rs439401 was associated with the susceptibility to EH in the Guizhou Han population and may have ethnic specificity (34). This evidence concerns the gene APOE and essential hypertension.