TNF and diabetes mellitus: To estimate systemic inflammation in individuals with TBDM and compare it to those with APTB without DM, the levels of inflammation mediators IL-8, IL-6, IL-10, TGF-β1, TNF-α, IFN-γ, CRP, and total sialic acid were measured prior to standard TB treatment and at the end of it (post-treatment) (Tables 4, 5).