In this study, we aimed to explore whether changes in systemic inflammation could be explained by a set of inflammatory mediators, including IL-6, IL-8, IL-10, interferon-gamma (IFN-γ), TNF-α, transforming growth factor beta 1 (TGF-β1), CRP, and total sialic acid, in subjects with APTB and those with TBDM before and after six months of standard TB treatment. Here, CRP is linked to tuberculosis.