Thus, the importance of the study lies in the fact that systemic inflammation can be evaluated with the determination of these inflammatory mediators (IFN-γ, CRP, and total sialic acid), and this evaluation could be useful in conjunction with sputum smear microscopy to evaluate the response to anti-tuberculosis treatment in subjects with APTB and TBDM [7,17,29,82]. Here, IFNG is linked to tuberculosis.