GRIN2B and autism: Based on some research, a decrease in the expression or function of the GRIN2B gene can impair NMDA-dependent signaling and can disrupt the excitatory-inhibitory balance of the middle area of the frontal lobe causing some autism-like behaviors such as social interaction disorders (Rudebeck et al., 2008; Yoo et al., 2012; Lee et al., 2016; Bell et al., 2018).