Increased retinal BDNF level was shown to be neuroprotective in optic nerve injury models, including glaucoma (Ritch and Sharma, 2000; Arancibia et al., 2008; Domenici et al., 2014; Sanna et al., 2017; Wójcik-Gryciuk et al., 2020). The gene discussed is BDNF; the disease is glaucoma.