Sposato et al. (2009) treated rats having elevated IOP with topical application of NGF. The results showed that increased IOP alters the basal content of NGF and NGF receptors in visual centers in brain and that NGF topical application normalized these deficits. These findings suggest that degeneration in retinal areas may contribute to a reduction in NGF levels. Following above, the clinical trial of topical application of NGF in glaucoma has been initiated (Beykin et al., 2022). The gene discussed is NGF; the disease is glaucoma.