Within the cross-diagnostic network of depression and anxiety, the strongest connection can be found between CESD10 (Sleep disturbances) and GAD1 (Nervousness or anxiety), followed closely by the associations between CESD1 (Feeling bothered) and GAD6 (Feeling nervous/fearful), as well as CESD6 (Feeling nervous/fearful) and GAD4 (Trouble relaxing). This evidence concerns the gene GAD1 and major depressive disorder.