IFNAR1 and Cognitive impairment: In this setting, cognitive impairment has been shown to occur both as consequence of IFNAR activation (McNab et al., 2015), via a relatively indolent synaptopathy due to the chronic accumulation and dissemination of neurotoxic molecules and proteopathic seeds (Baruch et al., 2014; Viengkhou and Hofer, 2023).