Tissue specific activation of the interferon alpha and beta receptor subunit 1 (IFNAR1) and the C-X-C Motif Chemokine Ligand 10 - C-X-C Motif Chemokine Receptor 3 (CXLC10-CXCR3) axis in murine brain endothelial and epithelial cells may manifest as cognitive impairment (Blank et al., 2016). This evidence concerns the gene IFNAR1 and Cognitive impairment.