To probe into IFN-I dysregulation, we had focused on the interferon induced transmembrane protein 3 (IFITM3) (Vavougios et al., 2021b), an innate immunity protein effective against multiple pathogens, including SARS-CoV-2 (Prelli Bozzo et al., 2021) and a modulator of beta-amyloidogenesis, with an emerging role in the pathogenesis of Alzheimer’s disease (Hur et al., 2020). Here, IFITM3 is linked to early-onset autosomal dominant Alzheimer disease.