VEGFA and coronary artery disorder: In terms of age, erectile function declines with men's age, a finding confirmed in recent studies (21, 22), and the mechanism may be related to the decline in testosterone levels and the large deposition of collagen fibers in the penile corpus cavernosum (23); with age, vascular endothelial growth factor (VEGF) becomes markedly under-signaled, leading to a decline in vascular endothelial function, an obvious trigger for coronary heart disease (24, 25).