Notably, our findings showed that high NLRP3 expression was associated with age ≤ 50 years (p = 0.022) and premenopausal status (p = 0.012); high cleaved caspase-1 p20 expression was associated with nonendometrioid carcinoma (p = 0.008), FIGO grade 3 disease (p = 0.020), and a p53 mutant pattern (p = 0.003); high cleaved gasdermin D expression was associated with BMI > 25 kg/m2 (p = 0.049), FIGO grades 1–2 (p = 0.014), early FIGO stage (I–II) (p = 0.030), and absence of lymph node metastasis (p = 0.042); and high CHMP4B expression was associated with nonendometrioid carcinoma (p = 0.028). This evidence concerns the gene NLRP3 and metastatic malignant neoplasm in the lymph nodes.