Notably, cleaved gasdermin D-high/CHMP4B-low endometrial cancer was associated with endometrioid carcinoma (p = 0.010) and FIGO grade 1–2 (p = 0.023), whereas cleaved gasdermin D-high/CHMP4B-low endometrial cancer was significantly associated with endometrioid carcinoma (p = 0.010) and FIGO grades 1–2 (p = 0.023). This evidence concerns the gene CHMP4B and endometrial cancer.