While individuals with asthma and obesity seem to exhibit either no significant difference or an inverse relationship with eosinophilic airway inflammation compared to non-obese individuals with asthma (34, 138), evidence of airway inflammation was observed through higher levels of IL-5, IL-17A, and IL-25 mRNA in individuals with both obesity and asthma (139). This evidence concerns the gene IL5 and obesity due to melanocortin 4 receptor deficiency.