Obesity-induced epithelial remodeling may involve various factors, including HMGB1, the role of leptin, CysLTs, ORMDL3, matrikines like PGP, and cytokines such as IL-4 and IFN-γ, which may contribute to epithelial alterations. Here, ORMDL3 is linked to obesity due to melanocortin 4 receptor deficiency.