The precise mechanism through which HMGB1 induces EMT in asthma remains unclear, but it may potentially involve RAGE and the phosphatidylinositol 3′ -kinase/Akt/glycogen synthase kinase 3β/β-catenin (PI3K/Akt/GSK3β/β-catenin) signaling pathway (92) or the RAGE/NF-κB signaling pathway (93). This evidence concerns the gene AGER and asthma.