Both activated Yap and β-catenin levels in the nucleus significantly increased in E. chaffeensis-infected APC KD cells compared to controls (uninfected APC KD cells and E. chaffeensis-infected and uninfected scRNA transfected cells), demonstrating that APC stabilizes activated Yap and β-catenin levels in the nucleus during infection (Figures 2B,C). The gene discussed is APC; the disease is infection.